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Full-Time
Hybrid

Principal Scientist, T Cell Immunology (Autoimmunity and Infectious Disease)

MModerna, Inc.325 Binney Street, Cambridge, MAUS$142,500 - US$256,500 per year
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Description

Moderna is seeking a Principal Scientist to lead immunology research in autoimmune and infectious disease programs. The role focuses on mechanistic discovery and translational immunology for mRNA-LNP therapeutics, requiring deep expertise in T cell biology, scientific leadership, and effective collaboration across multidisciplinary teams to advance programs from early discovery through IND-enabling studies and clinical enablement.

What We're Looking For

Lead preclinical research efforts in one or more autoimmune or infectious disease programs from early discovery through IND-enabling studies.,Establish preclinical models and perform T cell immune profiling to support target discovery, validation, and clinical enablement.,Drive translational research to elucidate therapeutic mechanism of action through analysis of human clinical samples.,Contribute to shaping program strategy from discovery through translational readiness, including indication fit, differentiation, competitive positioning, and risk management.,Build and present decision-focused data packages and program updates for internal governance.,Monitor the scientific literature and competitive landscape to identify opportunities (targets, mechanisms, modalities, biomarkers) that strengthen the portfolio.,Lead, mentor, and develop research associates and scientists through clear direction, goal setting, coaching, and performance management, fostering a culture of rigor, learning, and urgency.,Lead integrated program teams by aligning stakeholders on objectives, timelines, resourcing, and decision criteria across discovery, translational, and development partners.,Must already hold work authorization in US and be able to maintain that status without the need for future sponsorship.,Only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position due to export control laws.

Ideal Candidate

PhD in Immunology, Microbiology, or a related discipline, with a minimum of 5+ years of relevant post-graduate experience in academia and/or biotech/pharma, with a preference for allergy, autoimmune, or infectious disease experience.,Deep expertise in T cell immunobiology, with demonstrated experience in autoimmune or infectious disease immunology.,Strong hands-on experience with core immunology methods (e.g., multiparameter flow cytometry, intracellular cytokine staining, ELISPOT, antigen-specific stimulation).,Experience designing and interpreting in vivo disease models relevant to allergic or autoimmune inflammation; ability to connect model findings to human biology.,Proven leadership experience managing and developing researchers; ability to set direction, prioritize, and deliver in a matrixed organization.,Track record of scientific excellence demonstrated through publications, presentations, patents, and/or impactful contributions to therapeutic programs.,Excellent written and verbal communication skills, with the ability to influence across functions and engage external partners.,Curious, creative, and rigorous experimentalist with a bias for action and a commitment to high-quality data and reproducible science.

Minimum Education

PhD in Immunology, Microbiology, or a related discipline

Hard Skills

T cell biology/immunobiology
preclinical models establishment
T cell immune profiling
translational research
in vivo disease models (allergic/autoimmune inflammation)
multiparameter flow cytometry
intracellular cytokine staining
ELISPOT
antigen-specific stimulation
scientific literature monitoring

Soft Skills

Scientific leadership
collaboration
mentoring
developing researchers
goal setting
coaching
performance management
strategic thinking
risk management
presentation skills
written communication
verbal communication
influence
curiosity
creativity
rigor
bias for action
commitment to quality and reproducible science

Benefits

Best-in-class healthcare coverage
voluntary benefit programs
holistic well-being approach (fitness
mindfulness
mental health support)
family planning benefits (fertility
adoption
surrogacy)
generous paid time off (vacation
volunteer days
sabbatical
global recharge days
discretionary year-end shutdown)
savings and investment opportunities
location-specific perks and extras
annual discretionary bonus eligibility
other incentive compensation eligibility
equity award eligibility
smoke-free/alcohol-free/drug-free work environment

Special Commitments

Must be able to maintain US work authorization without future sponsorship.,Requires U.S. Person status (citizen, permanent resident, asylee, or refugee) due to export control regulations.

About the Company

M

Moderna, Inc.

Moderna is a biotechnology company pioneering a new class of medicines made of messenger RNA (mRNA). The company's platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases.

Innovative
Science-driven
Collaborative
Fast-paced
Mission-oriented
View all jobs at Moderna, Inc.

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