Moderna is seeking a Principal Scientist to lead immunology research in autoimmune and infectious disease programs. The role focuses on mechanistic discovery and translational immunology for mRNA-LNP therapeutics, requiring deep expertise in T cell biology, scientific leadership, and effective collaboration across multidisciplinary teams to advance programs from early discovery through IND-enabling studies and clinical enablement.
Lead preclinical research efforts in one or more autoimmune or infectious disease programs from early discovery through IND-enabling studies.,Establish preclinical models and perform T cell immune profiling to support target discovery, validation, and clinical enablement.,Drive translational research to elucidate therapeutic mechanism of action through analysis of human clinical samples.,Contribute to shaping program strategy from discovery through translational readiness, including indication fit, differentiation, competitive positioning, and risk management.,Build and present decision-focused data packages and program updates for internal governance.,Monitor the scientific literature and competitive landscape to identify opportunities (targets, mechanisms, modalities, biomarkers) that strengthen the portfolio.,Lead, mentor, and develop research associates and scientists through clear direction, goal setting, coaching, and performance management, fostering a culture of rigor, learning, and urgency.,Lead integrated program teams by aligning stakeholders on objectives, timelines, resourcing, and decision criteria across discovery, translational, and development partners.,Must already hold work authorization in US and be able to maintain that status without the need for future sponsorship.,Only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position due to export control laws.
PhD in Immunology, Microbiology, or a related discipline, with a minimum of 5+ years of relevant post-graduate experience in academia and/or biotech/pharma, with a preference for allergy, autoimmune, or infectious disease experience.,Deep expertise in T cell immunobiology, with demonstrated experience in autoimmune or infectious disease immunology.,Strong hands-on experience with core immunology methods (e.g., multiparameter flow cytometry, intracellular cytokine staining, ELISPOT, antigen-specific stimulation).,Experience designing and interpreting in vivo disease models relevant to allergic or autoimmune inflammation; ability to connect model findings to human biology.,Proven leadership experience managing and developing researchers; ability to set direction, prioritize, and deliver in a matrixed organization.,Track record of scientific excellence demonstrated through publications, presentations, patents, and/or impactful contributions to therapeutic programs.,Excellent written and verbal communication skills, with the ability to influence across functions and engage external partners.,Curious, creative, and rigorous experimentalist with a bias for action and a commitment to high-quality data and reproducible science.
PhD in Immunology, Microbiology, or a related discipline
Must be able to maintain US work authorization without future sponsorship.,Requires U.S. Person status (citizen, permanent resident, asylee, or refugee) due to export control regulations.
Moderna is a biotechnology company pioneering a new class of medicines made of messenger RNA (mRNA). The company's platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases.
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