Principal Scientist, Protein Design

Lead execution of in vitro selection and cell-surface screening campaigns, providing technical leadership through direct involvement in experimental design and execution.,Design and run high-throughput mammalian display campaigns for complex, multimeric glycoproteins.,Build and deploy scalable screening systems that replace resource-intensive plate-based assays.,Develop and operationalize advanced in vitro selection and directed-evolution capabilities, including novel selection pressures and expanded mammalian display modalities.,Serve as a key experimental partner to computational protein design teams, generating high-quality datasets and actionable design feedback.,Provide technical mentorship and scientific guidance to other scientists.,Represent in vitro selection capabilities in cross-functional discovery and platform discussions.,Mentor and technically guide junior scientists to elevate overall design quality.

PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering, or a related field.,5+ years of post-PhD industry or equivalent experience leading in vitro selection, mammalian cell-surface display, or directed-evolution efforts.,Demonstrated ability to drive complex screening campaigns end-to-end.,Deep expertise in mammalian display systems, high-throughput selection strategies, and experimental assay design.,Strong working knowledge of computational, structure-based, or AI-driven protein design workflows.,Scientific independence, judgment, and ownership consistent with a Principal Scientist role.,Expertise with glycoprotein antigen expression and engineering (e.g., strategies around folding, trafficking, cleavage, stability, and glycan impacts).,Strong capabilities in library design and construction (site-saturation, combinatorial, error-prone, DNA assembly), plus NGS-based readouts and quantitative enrichment analysis.

PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering, or a related field

Employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. Moderna is unable to sponsor non-U.S. persons to apply for an export control license for this role.