Full-Time

Hybrid

Principal Scientist, Computational Protein Design

MModerna, Inc.325 Binney Street, Cambridge, MAUS$142,500 - US$256,500 per year

Description

This role at Moderna involves supporting protein design for vaccines and biologics within the mRNA pipeline. It's a hands-on scientific position for an experienced designer proficient in protein structure, binding interfaces, and computational design methods. The Principal Scientist will lead multiple high-impact programs, designing antigens, binders, and antibodies using advanced deep learning and structure-based tools. They will collaborate with experimental, immunology, and discovery teams, interpret data to drive iterative design cycles, and help develop protein design rules for mRNA delivery. The role also includes shaping design standards, mentoring junior designers, and acting as a scientific leader in computational protein design.

What We're Looking For

Serve as the computational protein design lead for vaccine and biologics programs, owning design strategy and technical decision-making.,Design antigens, binders, and antibodies using state-of-the-art design approaches.,Partner closely with experimental teams by interpreting data from in vitro selection and screening efforts to drive iterative design cycles.,Provide design guidance on library construction, mutational strategies, and hypothesis testing.,Mentor and technically guide junior designers to elevate overall design quality.,Contribute to cross-functional program strategy discussions.

Ideal Candidate

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Minimum Education

PhD

Hard Skills

Protein design

Computational design methods

Deep learning

Structure-based design

Python

Rosetta

ProteinMPNN

Soft Skills

Mentorship

Technical guidance

Leadership

Collaboration

Problem-solving

Bold

Relentless

Curious

Collaborative

Benefits

Best-in-class healthcare coverage

voluntary benefit programs

holistic well-being approach (fitness, mindfulness, mental health)

family planning benefits (fertility, adoption, surrogacy)

generous paid time off (vacation, volunteer days, sabbatical, global recharge days, discretionary year-end shutdown)

savings and investment opportunities

location-specific perks and extras.

Special Commitments

Position may involve access to U.S. export control laws (EAR) technology/data; employment contingent on ability to access export-controlled information; only U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible; Moderna unable to sponsor non-U.S. persons for an export control license.

About the Company

Moderna, Inc.

Moderna is a biotechnology company pioneering a new class of medicines made of messenger RNA (mRNA). The company's platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases.

Innovative

Science-driven